Aggressive therapies – including surgery, radiation and high-dose chemotherapy – have improved outcomes for medulloblastoma patients, but many patients still die of their disease, and survivors suffer severe long-term side effects from therapy.
https://wechsler-reya.org/wp-content/uploads/2018/11/admin-ajax.-226-sq.png226226Academic Web Pages/wp-content/themes/awp-enfold/blank.pngAcademic Web Pages2018-11-12 16:32:202023-02-28 15:07:52Discovering oncogenic drivers and creating models
Most medulloblastoma research has focused on the primary tumors growing in the cerebellum. However, most medulloblastoma patients do not die from the primary disease, but from leptomeningeal metastasis: the dissemination of tumor cells from the cerebellum into the brain and spinal cord.
https://wechsler-reya.org/wp-content/uploads/2018/11/Leptomeningeal-metastasis-section-color-adjusted-300.jpg300300Academic Web Pages/wp-content/themes/awp-enfold/blank.pngAcademic Web Pages2018-11-12 16:31:522023-02-28 15:07:53Elucidating the molecular mechanisms of metastasis
Genomic analyses have revealed that medulloblastoma is an extremely heterogeneous disease, with at least 4 distinct subtypes that differ in terms of mutations, gene expression, epigenetic changes, and patient survival.
https://wechsler-reya.org/wp-content/uploads/2018/11/Tumor-Homing-Peptides-in-MP-tumor-BRIGHTER-300x300.jpg300300Academic Web Pages/wp-content/themes/awp-enfold/blank.pngAcademic Web Pages2018-11-12 16:31:092023-02-28 15:07:53Identifying new therapeutics & approaches to drug delivery
Immunotherapy is emerging as a powerful approach to treating cancer. Antagonists of immune checkpoint regulators, T lymphocytes engineered to recognize tumor antigens, and vaccines that amplify tumor-specific lymphocytes are being tested against a variety of human malignancies.
https://wechsler-reya.org/wp-content/uploads/2018/11/wech-reya-research-image-4-sq.jpg300300Academic Web Pages/wp-content/themes/awp-enfold/blank.pngAcademic Web Pages2018-11-12 16:30:332023-02-28 15:07:54Harnessing the immune system to target tumors
Discovering oncogenic drivers and creating models
/in ResearchAggressive therapies – including surgery, radiation and high-dose chemotherapy – have improved outcomes for medulloblastoma patients, but many patients still die of their disease, and survivors suffer severe long-term side effects from therapy.
Elucidating the molecular mechanisms of metastasis
/in ResearchMost medulloblastoma research has focused on the primary tumors growing in the cerebellum. However, most medulloblastoma patients do not die from the primary disease, but from leptomeningeal metastasis: the dissemination of tumor cells from the cerebellum into the brain and spinal cord.
Identifying new therapeutics & approaches to drug delivery
/in ResearchGenomic analyses have revealed that medulloblastoma is an extremely heterogeneous disease, with at least 4 distinct subtypes that differ in terms of mutations, gene expression, epigenetic changes, and patient survival.
Harnessing the immune system to target tumors
/in ResearchImmunotherapy is emerging as a powerful approach to treating cancer. Antagonists of immune checkpoint regulators, T lymphocytes engineered to recognize tumor antigens, and vaccines that amplify tumor-specific lymphocytes are being tested against a variety of human malignancies.