Selected Publications

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.

Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Northcott PA, Wechsler-Reya RJ


Nature Communications 10:332, 2019.

Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma.

Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ.


Cancer Research 79(9):2208-2219, 2019.

A hematogenous route for medulloblastoma leptomeningeal metastases.

Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD


Cell 172(5):1050-1062, 2018.

Medulloblastoma: From molecular subgroups to molecular targeted therapies.

Wang J, Garancher A, Ramaswamy V, Wechsler-Reya RJ


Annual Review of Neuroscience 41:207-232, 2018.

NRL and CRX define photoreceptor identity and reveal subgroup-specific dependencies in medulloblastoma.

Garancher A, Lin CY, Morabito M, Richer W, Rocques N, Larcher M, Bihannic L, Smith K, Miquel C, Leboucher S, Herath NI, Dupuy F, Varlet P, Haberler C, Walczak C, El Tayara N, Volk A, Puget S, Doz F, Delattre O, Druillennec S, Ayrault O, Wechsler-Reya RJ, Eychène A, Bourdeaut F, Northcott PA, Pouponnot C


Cancer Cell 33(3):435-449e6, 2018.

Brain tumor stem cells remain in play.

Parada LF, Dirks PB, Wechsler-Reya RJ


Journal of Clinical Oncology 35(21):2428-2431, 2017.

Molecular mechanisms and therapeutic targets in pediatric brain tumors.

Liu KW, Pajtler KW, Worst BC, Pfister SM, Wechsler-Reya RJ


Science Signaling; 10(470), 2017.

MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition.

Mollaoglu G, Guthrie MR, Böhm S, Brägelmann J, Can I, Ballieu PM, Marx A, George J, Heinen C, Chalishazar MD, Cheng H, Ireland AS, Denning KE, Mukhopadhyay A, Vahrenkamp JM, Berrett KC, Mosbruger TL, Wang J, Kohan JL, Salama ME, Witt BL, Peifer M, Thomas RK, Gertz J, Johnson JE, Gazdar AF, Wechsler-Reya RJ, Sos ML, Oliver TG


Cancer Cell 31(2):270-285, 2017.

Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo.

Medina DX, Householder KT, Ceton R, Kovalik T, Heffernan JM, Shankar RV, Bowser RP, Wechsler-Reya RJ, Sirianni RW


Journal of Controlled Release 253:172-182, 2017.

Differential immune microenvironments and response to immune checkpoint blockade among molecular subtypes of murine medulloblastoma.

Pham CD, Flores C, Yang C, Pinheiro EM, Yearley JH, Sayour EJ, Pei Y, Moore C, McLendon RE, Huang J, Sampson JH, Wechsler-Reya R, Mitchell DA


Clinical Cancer Research 22(3):582-95, 2016.

HDAC and PI3K antagonists cooperate to inhibit growth of MYC-driven medulloblastoma.

Pei Y, Liu KW, Wang J, Garancher A, Tao R, Esparza LA, Maier DL, Udaka YT, Murad N, Morrissy S, Seker-Cin H, Brabetz S, Qi L, Kogiso M, Schubert S, Olson JM, Cho YJ, Li XN, Crawford JR, Levy ML, Kool M, Pfister SM, Taylor MD, Wechsler-Reya RJ


Cancer Cell 29(3):311-323, 2016.

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.

Brun SN, Markant SL, Esparza LA, Garcia G, Terry D, Huang JM, Pavlyukov MS, Li XN, Grant GA, Crawford JR, Levy ML, Conway EM, Smith LH, Nakano I, Berezov A, Greene MI, Wang Q, Wechsler-Reya RJ


Oncogene 34(29):3770-9, 2015.

Cancer For pediatric glioma, leave no histone unturned.

Becher OJ, Wechsler-Reya RJ


Science 346(6216):1458-9, 2014.

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jäger N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turányi E, Hauser P, Sanden E, Darabi A, Siesjö P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ, Pfister SM


Nature 511(7510):428-34, 2014.

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Kool M, Jones DT, Jäger N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, Rausch T, Shih D, Reimand J, Sieber L, Wittmann A, Linke L, Witt H, Weber UD, Zapatka M, König R, Beroukhim R, Bergthold G, van Sluis P, Volckmann R, Koster J, Versteeg R, Schmidt S, Wolf S, Lawerenz C, Bartholomae CC, von Kalle C, Unterberg A, Herold-Mende C, Hofer S, Kulozik AE, von Deimling A, Scheurlen W, Felsberg J, Reifenberger G, Hasselblatt M, Crawford JR, Grant GA, Jabado N, Perry A, Cowdrey C, Croul S, Zadeh G, Korbel JO, Doz F, Delattre O, Bader GD, McCabe MG, Collins VP, Kieran MW, Cho YJ, Pomeroy SL, Witt O, Brors B, Taylor MD, Schüller U, Korshunov A, Eils R, Wechsler-Reya RJ, Lichter P, Pfister SM


Cancer Cell 25(3):393-405, 2014.

SnapShot: Medulloblastoma.

Rusert JM, Wu X, Eberhart CG, Taylor MD, Wechsler-Reya RJ


Cancer Cell 26(6):940-940e1, 2014.

A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity.

Li P, Du F, Yuelling LW, Lin T, Muradimova RE, Tricarico R, Wang J, Enikolopov G, Bellacosa A, Wechsler-Reya RJ, Yang ZJ


Nature Neuroscience 16(12):1737-44, 2013.

Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma.

Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ


Oncogene 32(35):4181-8, 2013.

Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases.

Markant SL, Esparza LA, Sun J, Barton KL, McCoig LM, Grant GA, Crawford JR, Levy ML, Northcott PA, Shih D, Remke M, Taylor MD, Wechsler-Reya RJ


Cancer Research 73(20):6310-22, 2013.

An animal model of MYC-driven medulloblastoma.

Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, Northcott PA, Taylor MD, Pfister SM, Febbo PG, Wechsler-Reya RJ


Cancer Cell 21(2):155-67, 2012.

Spheres without influence: dissociating in vitro self-renewal from tumorigenic potential in glioma.

Read TA, Wechsler-Reya RJ


Cancer Cell 21(1):1-3, 2012.

WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum.

Pei Y, Brun SN, Markant SL, Lento W, Gibson P, Taketo MM, Giovannini M, Gilbertson RJ, Wechsler-Reya RJ


Development 139(10):1724-33, 2012.

Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.

Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ


Cancer Cell 15(2):135-47, 2009.

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

Kessler JD, Hasegawa H, Brun SN, Emmenegger BA, Yang ZJ, Dutton JW, Wang F, Wechsler-Reya RJ


Genes & Development 23(2):157-70, 2009.

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.

Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ


Cancer Cell 14(2):135-45, 2008.

Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.

Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG, Wechsler-Reya RJ


Proceedings of the National Academy of Sciences 104(8):2973-8, 2007.

Isolation of neural stem cells from the postnatal cerebellum.

Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE, Wechsler-Reya RJ


Nature Neuroscience 8(6):723-9, 2005.

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ


Development 132(10):2425-39, 2005.

Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.

Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ


Proceedings of the National Academy of Sciences 100(12):7331-6, 2003.

The developmental biology of brain tumors.

Wechsler-Reya R, Scott MP


Annual Review of Neuroscience 24:385-428, 2001.

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.

Wechsler-Reya RJ, Scott MP


Neuron 22(1):103-14, 1999.