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Wechsler-Reya Lab - Neural Development and Tumorigenesis
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Below are some of the publications from our lab. Click the "open pdf" link to open the publication in a new window.

A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity
Li, P, Du, F, Yuelling, LW, Lin, T, Muradimova1, RE, Tricarico1, R, Wang, J, Enikolopov, G, Bellacosa1, A, Wechsler-Reya RJ and Yang, ZJ Nature Neurosci (2013) doi:10.1038/nn.3553
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Targeting Sonic Hedgehog-Associated Medulloblastoma through Inhibition of Aurora and Polo-like Kinases
Markant, SL, Esparza, LA, Sun, J, Barton, KL, McCoig, LM, Grant, GA, Crawford, JR, Levy, ML, Northcott, PA, Shih, D, Remke, M, Taylor, MD, and Wechsler-Reya, RJ Cancer Research (2013) doi: 10.1158/0008-5472 / CAN-12-4258
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WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum
Pei, Y, Brun, SM, Markant, SL, Lento, W, Gibson, P, Taketo, MM, Giovannini, M, Gilbertson, RJ and Wechsler-Reya, RJ. Development (2012) 139:1694-1703.
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Matching mice to malignancy: molecular subgroups and models of medulloblastoma.
Lau, J, Schmidt, C. Markant, SL, Taylor, MD, Wechsler-Reya, RJ and Weiss, WA. Childs Nervous System (2012) [Epub ahead of print]
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An Animal Model of MYC-Driven Medulloblastoma.
Pei, Y., Moore, CE, Wang, J, Tewari, AK, Eroshkin, A, Cho, Y-J, Witt, H, Korshunov, A, Read, TA, Sun, JL, Schmitt, EM, Miller, CR, Buckley, AF, McLendon, RE, Westbrook, TF, Northcott, PA, Taylor, MD, Pfister, SM, Febbo, PG and Wechsler-Reya, RJ (2012) Cancer Cell 21:155–167.
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Spheres without influence: Dissociating in vitro self-renewal from tumorigenic potential in glioma.
Read, TA and Wechsler-Reya RJ (2012) Cancer Cell 21:1-3.
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Personalized mice: modeling the molecular heterogeneity of medulloblastoma.
Markant, SL, Wechsler-Reya RJ (2011) Neuropathol Appl Neurobiol Nov 9 doi:10.111/j.1365-2990.2011.01235.x. [Epub ahead of print]
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Subtypes of medulloblastoma have distinct developmental origins.
Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg, T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang Z-J, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya RJ and Gilbertson RJ (2010) Nature 486:1095-99.
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A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas.
Pei Y and Wechsler-Reya RJ (2010) Cancer Cell 18:546-7.
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Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG and Wechsler-Reya RJ (2009) Cancer Cell 15:135-147.
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N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.
Kessler JD, Hasegawa H, Brun SN, Emmenegger BA, Yang ZJ, Dutton JW, Wang and Wechsler-Reya RJ (2009) Genes Dev 23:157-70.
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Stem cells and the origin and propagation of brain tumors.
Emmenegger BA and Wechsler-Reya RJ (2008) J Child Neurol 23:1172-78.
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Medulloblastoma can be initiated by deletion of patched in lineage-restricted progenitors or stem cells.
Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ and Wechsler-Reya RJ (2008) Cancer Cell 14:135-45.
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Hit ‘em where they live: Targeting the cancer stem cell niche.
Yang ZJ and Wechsler-Reya RJ (2007) Cancer Cell 11:3-5.
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Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.
Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG and Wechsler-Reya RJ (2007) Proc Natl Acad Sci 104:2973-8.
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The neurobiology of neurooncology.
Read TA, Hegedus B, Wechsler-Reya R and Gutmann DH (2006) Ann Neurol 60:3-11.
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Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog.
Wechsler-Reya RJ and Scott MP (1999) Neuron 22:103-114.
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The developmental biology of brain tumors.
Wechsler-Reya RJ and Scott MP (2001) Annu Rev Neurosci 24:385-428.
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Caught in the matrix: How vitronectin controls neuronal differentiation.
Wechsler-Reya RJ (2001) Trends Neurosci 24:680-2.
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Analysis of gene expression in the normal and malignant cerebellum.
Wechsler-Reya RJ (2003) Recent Prog Horm Res 58:227-248
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Transcriptional profiling of the hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.
Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP and Wechsler-Reya RJ (2003) Proc Natl Acad Sci 100:7331-6.
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Getting at the root and stem of brain tumors.
Oliver TG and Wechsler-Reya RJ (2004) Neuron 42:885-88.
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Morphing into cancer: the role of developmental signaling pathways in brain tumor formation.
Fogarty MP, Kessler JD and Wechsler-Reya RJ (2005) J Neurobiol 64:458-475.
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Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.
Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM and Wechsler-Reya RJ (2005) Development 132:2425-39.
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Isolation of neural stem cells from the postnatal cerebellum.
Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE and Wechsler-Reya RJ (2005) Nat Neurosci 8:723-9
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